A recent study has revealed that persons who have a variant of longevity gene called KLOTHO had better brain skills like judgment, knowledge and recollection, regardless of their age, sex or whether they have a genetic risk factor for Alzheimer’s disease
Researchers have also noticed that when KLOTHO gene levels were increased in mice, they became smarter. The phenomenon could be explained due to the strength of connection between nerve cells in the brain.
The research is headed by Dena Dubal, M.D., Ph.D., an assistant professor of neurology, the David A. Coulter Endowed Chair in Aging and Neuro-degeneration at the University of California San Francisco (UCSF). According to Dena, it could pave way to help millions of patients around the world who are suffering from Alzheimer’s disease and other forms of dementia caused by Brain degeneration. If it is possible to repair and boost the brain’s ability to function, we could be looking at a revolutionary new approach in treating dementia.
KLOTHO is a Greek Mythological goddess of fate who is tasked with spinning the thread of life. The study revealed that persons who have one copy of the variant of the KLOTHO gene and named KL-VS live longer and also have a lower risk of suffering from a stroke. Persons who carry two copies of the gene in their body live shorter with a higher risk of stroke.
Suzana Petanceska, Ph.D., program director in NIA’s Division of Neuroscience said, “This study shows the importance of genes that regulate the multiple aging processes involved in the maintenance of cognitive function. Understanding the factors that control the levels and activity of KLOTHO across multiple organ systems may open new therapeutic avenues for prevention of age-related cognitive decline and dementia.”
The study has been published in the Cell Reports.